Since 1953 ( 15), epidemiological studies ( 16, 17) have found blood type A has increased risk of gastric cancer.Several recent epidemiological studies ( 10, 11, 12, 13, 14) suggest O blood type has lower risk of pancreatic cancer.ABO blood groups appear to influence susceptibility to pancreatic and gastriccancers, cardiovascular disease and some infectious/communicablediseases (8 see below from 9) with type O tending to have lower risk.OTOH, for many decades little research was done on differential risk for many diseases with different blood groups but in recent years a steady drip of data supporting such associations has emerged.Thus far, being scientifically unsubstantiated is the only clear trait linking such tall claims (7). Almost on the heels of the 1900 ABO blood group discovery, people started trotting out associations of different blood types with various human traits, ranging from personality to appropriate diets, the so-called blood group diet being merely one of the latest such fads.Clearly, the ABO blood group system exemplifies the fact that human blood group antigens are under active, intensive evolutionary selection pressure.B is quite frequent in Central Asia but almost absent among Amerindians, who are almost exclusively O.A is mainly found in North and Central Europe, rarer in Asia.Ironically for molecules whose imprint on the public imagination is precisely their blood cell expression and ensuing need to match blood types during transfusion, their expression on human RBCs is an exception (see below from 4, 5).However, function they must have not only because that's nature's way but also because they are widely expressed, in endodermal origin tissues of more ancient species such as amphibians and reptiles while also being expressed in tissues of more recently evolved species such as rodents and primates.Though Karl Landsteiner discovered different blood groupa all the way back in 1900, hardly anything is known about their function.Of the roughly 35 different current blood group systems, the ABO blood group system is considered the most important (see below from 1, 2, 3), especially for transfusion medicine. ![]() īlood group is typically defined by presence or absence of certain antigens on the surface of RBCs ( Red blood cell). People with the same blood group have similar risk for various diseases, specifically certain cancers, cardiovascular disease, and increased susceptibility and more adverse outcome to some infectious/communicable diseases. Answer by Tirumalai Kamala, Immunologist. This question originally appeared on Quora. What are similarities of people having the same blood group?
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